Sweating : Causes, Symptoms, Diagnosis & Treatment

Last Updated: 10/09/2022

Sweating (hyperhidrosis) is an increased sweating, often with a sharp unpleasant odor, which is accompanied by subjective discomfort. Hyperhidrosis occurs with lesions of the peripheral and central parts of the nervous system that regulate sweating, hormonal failures, exogenous intoxication. To determine the cause of excessive sweating, special tests and a neurological examination are performed, and the hormonal profile is examined. To eliminate unpleasant symptoms, sedatives, methods of physiotherapy and psychotherapy are used.

general characteristics

Excessive sweating is a subjective complaint: patients notice that they sweat more than other people. A person finds wet sweat stains on clothes, not only in the armpits, but also on the chest or back. Sweating is combined with a cooling of the skin, an unpleasant pungent odor, which is well felt at a distance. Patients may note that a large amount of sweat appears only on certain parts of the body - for example, on the palms and feet, on the face. Increased sweating is provoked by stress, minor physical exertion, food intake.

The symptom also causes psychological disturbances: a person begins to experience a sense of shame, discomfort, avoid contact with others. Great inconvenience is caused by increased sweating of the palms, which interferes with professional activities, makes it difficult to get to know people, shaking hands. A short-term increase in sweating in response to physical labor or emotional upheaval is considered a variant of the norm, but persistent hyperhidrosis that disrupts quality of life is an indication for contacting a specialist.

Classification

The difficulty of identifying individual variants of excessive sweating is due to the great subjectivity in assessing symptoms. Depending on the frequency of occurrence, hyperhidrosis is classified into permanent, the severity of which does not depend on the season, seasonal, in which sweating increases during the hot months, and intermittent, characterized by periodic relapses. In clinical practice, it is important to classify a symptom by prevalence, according to which the following are distinguished:

  • Limited (local) hyperhidrosis . It is characterized by increased secretion of sweat glands in certain areas of the skin. In accordance with this, the local form is divided into facial, palmar, plantar, axillary (axillary) hyperhidrosis. This variant is more often associated with dysfunction of the apocrine glands.
  • Generalized hyperhidrosis . Increased sweating is observed over the entire surface of the skin. The development of such a disorder is due to the increased work of all sweat glands, which is often associated with changes in the hormonal background, infectious diseases, and other systemic pathological disorders.

Various pathogenetic mechanisms cause the division of pathologically increased sweat secretion into two forms: primary idiopathic, the causes of which have not been established, and secondary, caused by damage to various organ systems. Night sweats associated with chronic infectious processes or hormonal surges are classified into a separate species. Due to a special mechanism of development, doctors secrete stress sweating (the so-called "cold sweat"), provoked by an increased concentration of catecholamines (adrenaline) in the blood. Given the degree of social discomfort, there is:

  • a mild form of sweating that does not limit the patient's interaction with other people;
  • moderate hyperhidrosis, in which daily activity is somewhat limited and discomfort occurs when shaking hands, close contact with people;
  • a severe form, characterized by strong sweating with a pungent odor, which makes the patient avoid other people, provokes psychological disorders.

 

Causes of sweating

Causes of cold sweat

Increased sweating is often accompanied by a sharp cooling and blanching of the skin. Such a reaction normally occurs during severe emotional upheavals, but more often the appearance of cold sweat is caused by pathological conditions:

  • Migraine .
  • Severe pain syndrome .
  • Viral infections : mononucleosis, influenza.
  • Critical conditions : hypoglycemia, acute heart or respiratory failure.
  • Vegetative regulation disorders .
  • Intoxication : alcohol abuse, the formation of endogenous toxins in renal and liver failure.

Causes of General Sweating

Excessive sweating over the surface of the entire skin is a normal reaction in hot climates, after intense physical work. Persistent hyperhidrosis with no apparent cause is a sign of illness. To the appearance of increased general sweating lead to:

  • Endocrine diseases : thyrotoxicosis, menopause in women, pheochromocytoma, etc.
  • Infectious processes : brucellosis, malaria, HIV infection.
  • Oncological pathology : lymphogranulomatosis, non-Hodgkin's lymphomas, neoplastic syndrome.
  • Poisoning : the use of poisonous mushrooms, the ingestion of organophosphorus compounds.
  • Complications of pharmacotherapy : long-term use of cholinomimetics, anticholinesterase drugs.
  • Rare causes : Riley-Day syndrome, Cassirer acroasphyxia, polyneuropathy.

Causes of sweating head

Severe sweating in the face and scalp, accompanied by hot flashes or, conversely, a sharp pallor and coldness, develops in the presence of painful disorders. Local sweating of the head is caused by:

  • Nightmares, sleep disturbances .
  • VSD : increased activity of the sympathetic nervous system.
  • Neurological disorders : Parkinson's disease, neurosyphilis, stroke.
  • hypertensive crises .
  • Damage to the nerve trunks : tympanic string syndrome, Lucy Frey's auricotemporal syndrome.
  • Genetic diseases : Book syndrome, Jadasson-Lewandowski, Gamstorp-Wohlfarth.

Causes of night sweats in women

Women are more susceptible to various pathological reactions of the autonomic nervous system and hormonal disruptions, so hyperhidrosis is more common in them. Increased night sweats in women can provoke such diseases and conditions:

  • Hormonal changes : a few days before menstruation, in the first trimester of pregnancy, in the premenopausal period.
  • Neuropsychiatric pathology : multiple sclerosis, psychosis, depressive states.
  • Systemic connective tissue diseases : rheumatoid arthritis, lupus erythematosus, rheumatism.
  • Complications of pharmacotherapy : taking tranquilizers, antipsychotics, antihypertensive drugs.

Causes of night sweats in men

Normally, sweating increases at high air temperatures in the bedroom, when using synthetic bed linen. The unreasonable release of a large amount of sweat, causing the pillow and sheets to get wet, indicates the possible presence of a pathological process. In men, night sweats are most often caused by conditions such as:

  • Withdrawal syndrome: with the abuse of alcohol, narcotic substances.
  • Hormonal disruptions : in adolescence, middle and old age due to a decrease in testosterone levels.
  • Endocrine diseases : carcinoid syndrome, pheochromocytoma, damage to the hypothalamic-pituitary system.
  • tuberculosis infection.
  • Tumor and: testicular cancer, prostate cancer.
  • Rare causes : sarcoidosis, histiocytosis.

Causes of decreased sweating

A decrease in the secretion of sweat glands (anhidrosis), occurring against the background of normal health, is observed in older people due to natural age-related skin changes. Sweat production is markedly reduced in the following conditions and diseases:

  • Severe dehydration: with limited water intake, repeated vomiting and diarrhea.
  • Skin lesions : atrophic acrodermatitis, radiation dermatitis, scleroderma.
  • Hereditary pathologies : Sjögren's disease, ectodermal dysplasia.
  • Complications of pharmacotherapy : treatment with antiepileptic drugs, ganglio- and anticholinergics.

Diagnostics

The primary diagnostic search for excessive sweating is carried out by a specialist therapist or general practitioner. The main task of the survey is to identify violations of the body, which provoked changes in the mode of operation of the sweat glands. For this purpose, special functional tests, laboratory tests and instrumental visualization methods are prescribed. The most valuable for diagnosis are:

  • Quantitative and qualitative tests . To clarify the degree of excessive sweating, a gravimetric method is useful, which involves weighing a piece of filter paper after 1 minute of contact with the skin. Minor's test is used to measure the area of ​​hyperhidrosis. Verification of the primary form of increased sweating is carried out using the chromatographic method.
  • Laboratory Research . The levels of the main hormones are measured - corticosteroids, thyroxine, tropic substances of the pituitary gland. Women are required to perform an analysis of the level of estrogen and progesterone. To exclude diabetes mellitus, fasting glycemia is determined, according to indications, a glucose load test is prescribed. In blood tests, they look for signs of inflammatory and tumor processes.
  • Neurological examination . The appearance of increased sweating is often associated with pathologies of the nervous system, so all patients are examined by a neurologist. In addition to physical examination and evaluation of the main reflexes, EEG and ultrasonography of peripheral nerves are used. According to indications, CT and MRI of the brain are prescribed.

When organizing a further examination, accompanying symptoms are taken into account: with signs of an infectious process, serological reactions are performed, with autoimmune diseases, the levels of rheumatoid factor and other specific markers are measured. Some patients are recommended to undergo a psychiatric evaluation. To diagnose doubtful cases of excessive sweating, they resort to the consultations of other specialists (dermatologist, infectious disease specialist, oncologist).

Antiperspirants reduce sweat and neutralize odor

 

Treatment

Help before diagnosis

To reduce the unpleasant smell of sweat and prevent irritation, it is necessary to take a hygienic shower at least 2 times a day, use underwear made from natural fabrics and loose clothing that does not rub the skin. In some cases, herbal sedatives are effective, which normalize the functioning of the nervous system and reduce psychological discomfort. With increased sweating, it is necessary to consult a specialist to find out the cause of hyperhidrosis and select the optimal treatment regimen.

Conservative therapy

Medical tactics for sweating are aimed both at stopping the underlying disease and at reducing subjective discomfort. Medicines are combined with physiotherapy methods - reflexology, electrophoresis with anticholinergic solutions. To eliminate psychological problems associated with increased sweat production, individual psychotherapy sessions are offered. The most commonly used drugs for the treatment of hyperhidrosis are:

  • Sedative drugs . Sedatives normalize the autonomic regulation of sweating, reduce the functional activity of the apocrine sweat glands. In severe hyperhidrosis, tranquilizers are used.
  • Means of local action . Cholinolytics are often used. Effective drugs with tannic properties - aluminum salts, plant extracts, which reduce the production of sweat and reduce irritation of the skin.
  • Hormonal preparations . They are used as replacement therapy for various endocrine disorders. In most cases, after the correction of the hormonal background, excessive sweating completely disappears.
  • Antibacterial agents . Antibiotics help prevent secondary bacterial skin lesions in areas of constant friction. Widely used for etiotropic therapy of infections accompanied by hyperhidrosis.
  • Botulinum toxin . The drug is used in the local form of sweating, injected subcutaneously or intradermally. The tool blocks the transmission of nerve impulses to the sweat glands, which helps to reduce sweating.

Surgery

In severe forms of excessive sweating, refractory to conservative therapy, resort to stem endoscopic thoracic sympathectomy. Due to the destruction of nerve fibers that stimulate the work of the sweat glands, a persistent decrease in sweating is achieved. With local axillary hyperhidrosis, curettage (curettage) of the inner surface of the skin and partial excision of the dermis in the armpit are effective. Sometimes an open adenotomy is used.

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