Tremor When Moving : Causes, Symptoms, Diagnosis & Treatment

Last Updated: 24/09/2022

Tremor during movement (intentional) occurs with lesions of the cerebellum, brain stem and red nuclei. Changes in brain structures develop against the background of TBI, strokes, tumors, degenerative diseases of the central nervous system, poisoning, and an overdose of certain drugs. The symptom is observed in isolation or combined with postural trembling and resting tremor. Neurological examination data and neuroimaging methods are used to determine the cause of movement tremor. Treatment is carried out with the use of valproates, beta-blockers, benzodiazepines. Operations are performed according to indications.

general characteristics

Tremor during movement or intentional trembling is a variant of hyperkinesis that occurs in the final phase of purposeful movements and intensifies as you approach the goal. Affects fine motor skills, limits or makes it impossible to perform precise movements. Absent at rest. It is often supplemented by the inability to maintain a fixed muscle tension, increased fatigue, and muscle hypotension.

The jitter frequency is 3-5 Hz. With damage to the cerebellum, a combination of tremor during movements and cerebellar ataxia is observed. The symptom develops against the background of damage to the superior cerebellar peduncle or lateral cerebellar nuclei. The severity varies significantly, both slight jerky and large-scale movements are possible, turning into asynergy or chorea. In pathological foci of other localizations, intentional tremor is combined with other types of trembling.

Why does tremor occur during movement

Acute cerebellar ataxia

This type of cerebellar ataxia develops over a period of several hours to one week. Movement tremor is associated with unsteady gait, loss of synergy, nystagmus, dysarthria, and instability in the Romberg position. The most common cause of this symptom complex is an ischemic stroke in the basin of the vertebrobasilar artery. It is manifested by dizziness, diplopia, dysarthria, dysphagia, hearing impairment. Alternating syndromes are often detected.

Less common is movement tremor due to hemorrhagic stroke. The symptom is also provoked by moderate and severe brain injuries. When the cerebellum is compressed by an intracerebral hematoma, it can occur both immediately and some time after damage. Sometimes the cause of the sudden onset of intentional tremor is encephalitis and Guillain-Barré syndrome. The symptom is observed in some patients with obstructive hydrocephalus, metabolic disorders and acute intoxications.

Tremor when moving

 

Subacute cerebellar ataxia

The same symptoms are noted as with an acute variety of pathology, but the clinical picture is formed in the period from one week to several months. Movement tremor may be accompanied by the following pathological conditions:

  • Intracerebral neoplasias: ependymomas, medulloblastomas, hemangioblastomas, astrocytomas, meningiomas.
  • Normal pressure hydrocephalus: after meningitis, subarachnoid hemorrhage, surgery.
  • Paraneoplastic syndrome: with non-Hodgkin's lymphoma, ovarian cancer, lung cancer.
  • Endocrine diseases : hypothyroidism, hyperparathyroidism.
  • Other causes : beriberi, an overdose of anticonvulsants.

Chronic cerebellar ataxia

There may be a gradual increase in symptoms over several months or years. Violation is observed in such cases as:

  • Addictions : alcoholism, polydrug addiction, substance abuse.
  • Hereditary diseases : olivopontocerebellar degeneration, Holmes' cerebellar atrophy, Pierre-Marie's ataxia, spinocerebellar ataxia, Friedreich's ataxia.
  • Oncological processes : tumors of the cerebellum with slow growth.

Multiple sclerosis

Multiple sclerosis is characterized by a variable clinical picture with a predominance of paresis. Tremor during movements may appear suddenly or progress gradually, combined with other signs of cerebellar damage: static and dynamic ataxia, asynergy, chanted speech, megalography. The involvement of the dentate-red nuclear pathways is accompanied by an increase in trembling, especially when changing the direction of movement. In severe cases, the tremor spreads from the arms to the trunk and head.

Wilson's disease

The first symptoms of this hereditary disease usually appear before the age of 3 years. Intentional tremor is the leading symptom of the trembling form; it may be absent in other variants of the course of Wilson's disease. Complemented by epileptic seizures, bradilalia, bradykinesia, severe psychoorganic syndrome.

Essential tremor

The leading symptoms of a hereditary disease are intentional and postural trembling. Sometimes there is a resting tremor. The hands are most commonly affected. Involvement of the head, tongue, lips and chin is possible. The symptom intensifies with emotional experiences and physical exertion. Due to severe tremor in patients with essential tremor, working capacity decreases, there is constant psychological discomfort, which provokes the development of neurotic disorders.

Diagnostics

The cause of the symptom is determined by a neurologist. At the initial stage of the examination, the specialist finds out when the tremor first appeared during movements, how often it appears, with what symptoms it is combined. To form a complete picture of disorders of the nervous system, a neurological examination is performed. Objective tests, instrumental and laboratory techniques are used to assess the nature and severity of trembling.

As objective tests, tremor assessment scales are used, the patient is asked to pour water from a bowl, draw a spiral. During the Gibson-Khersonsky test, the patient's handwriting is studied when writing with his eyes closed. The list of additional studies includes the following methods:

  • Tremorometry . It is prescribed to assess the frequency and amplitude of tremor, coordination and accuracy of movements. It is of high importance in determining the degree of impairments that limit the possibilities of self-service and the performance of professional operations involving fine motor skills.
  • Studies of the vestibular analyzer . To exclude vestibular disorders and their differentiation with cerebellar ataxia, the examination plan includes vestibulometry, stabilography, and electronystagmography.
  • Neuroimaging . Diagnosis of diseases accompanied by tremor during movements is carried out using MRI, MSCT of the brain. The techniques are effective for post-traumatic hematomas, neoplasms, degenerative changes and congenital anomalies. Suspicion of cerebellar ataxia of a vascular nature is considered an indication for doppler sonography or MRA.
  • Electrophysiological Methods . Electromyography helps to distinguish between movement tremors and other movement disorders. When recording the surface total EMG, repeated volleys are recorded with a certain amplitude and frequency, between which there are sections of the isoline.
  • Lumbar puncture. It is performed if there is a suspicion of a connection between cerebellar ataxia and traumatic brain injury, tumors, encephalitis. According to the results of the analysis of the cerebrospinal fluid, signs of intracranial hypertension or an inflammatory process are revealed, blood impurities are determined during hemorrhages.
  • Laboratory tests . To establish the infectious genesis of tremor during movements, a blood test for sterility is performed, and PCR is done. The hereditary nature of intentional trembling is confirmed using genetic analyzes and DNA diagnostic data.

Neurologist's consultation

 

Treatment

Conservative therapy

Tremor treatment during movements includes etiopathogenetic and symptomatic measures. The leading role is played by symptomatic drug therapy. To correct intentional tremor, drugs of the following groups are used:

  • Beta blockers . The mechanism of action has not been fully elucidated. The initial dose of propranolol or anaprilin is 1 mg. The medication is taken 3 times a day. The dose is gradually increased to 24 mg per day. The disadvantages of this group of drugs are frequent cancellations due to side effects (bradycardia, fatigue), the need to gradually stop taking them.
  • Benzodiazepines . They have a muscle relaxant and anticonvulsant effect. The daily dose of clonazepam or diazepam is 4-6 mg. The most common side effects are drowsiness and dizziness. With prolonged use, addiction is observed.
  • Valproates . They reduce the severity of tremor during movement due to the effect on the metabolism of gamma-aminobutyric acid. Medicines are taken in a daily dose of 300-60 mg. In the treatment of drugs of this group, nausea, stool disorders are possible.

Non-drug methods include measures to correct trembling and adapt to disorders. Patients are advised, if possible, to exclude situations that increase the intensity of tremor during movement. To minimize the negative impact of the symptom on the performance of household activities, it is recommended to use spoons and forks with thick handles, special fountain pens, knives and scissors with rounded ends, and telephones with voice control.

Orthoses that fix the hand in the area of ​​the wrist joint help to reduce the severity of intentional tremor. To master new motor stereotypes, patients are prescribed exercise therapy and occupational therapy in combination with reflexology and massage. Etiopathogenetic measures include vascular and anti-inflammatory drugs, hormonal drugs.

Patients with cancer may need chemotherapy and radiation therapy. Tremor during movements on the background of alcoholism and drug addiction is an indication for the treatment of addictions in a narcological hospital with subsequent rehabilitation.

Surgery

The tactics of surgical intervention is determined by the characteristics of the pathological process that provoked tremor during movements:

  • TBI : transcranial removal, stereotaxic aspiration, or endoscopic evacuation of an intracerebral hematoma.
  • Circulatory disorders : thrombolysis in ischemic stroke, formation of vascular anastomoses, arterial reconstruction, endarterectomy, aneurysm occlusion.
  • Tumors : Surgical removal and stereotactic radiosurgery of brain neoplasms.

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