Pain in the urethra is accompanied by urethritis, stones, foreign bodies, traumatic injuries, benign and malignant neoplasms of the urethra. It is detected in conditions accompanied by chronic obstruction of the urethra, some andrological and gynecological pathologies. Most often it has a cutting character, associated with urination. To establish the cause of the symptom, complaints are collected, an external examination, imaging and laboratory studies are carried out. Treatment includes antibacterial agents, NSAIDs, immunostimulants, physiotherapy, and surgical interventions.