Pain in the gallbladder most often indicates biliary dyskinesia, acute or chronic cholecystitis, cholelithiasis. Less commonly, pain syndrome occurs against the background of cholangitis, parasitic invasions, neoplasms. For the diagnosis of etiological factors, instrumental visualization is used - ultrasound, cholecystography, ERCP, scintigraphy. Laboratory techniques include bile analysis, clinical and biochemical blood tests. To stop the symptom, painkillers and antispasmodics, antibiotics, choleretic drugs are prescribed. According to the indications, surgical treatment is performed - cholecystectomy.