Malaise is an unpleasant feeling of weakness, causeless fatigue, loss of interest in the usual activities. The condition is often accompanied by mild muscle, joint and headaches, occasional dizziness, and sometimes fever. The symptom is characteristic of most diseases, the development of malaise may be associated with a violation of the daily routine and nutrition. To determine the causes of the disorder, a complex of laboratory tests, ultrasound and other imaging methods, and a neurological examination are performed. To eliminate the manifestations, combinations of non-drug methods and drugs of various pharmaceutical groups are used.