Skin itching is a common symptom of skin, allergic, infectious, metabolic, hematological, psychogenic diseases. It can be localized or spread to a significant part of the skin. Itching is accompanied by scratching and inflammation of the skin, rash, increased irritability, sleep disturbance. The etiofactors of pruritus are determined by dermatological examination (luminescent diagnostics, trichoscopy), allergy tests, laboratory tests (scraping microscopy), and skin biopsy. Treatment includes topical and systemic pharmacotherapy, physiotherapy, psychotherapy.