Tonic-clonic convulsions are mixed paroxysms in which prolonged tonic spasms are replaced by rapid clonic contractions of the skeletal muscles. The causes of generalized seizures are quite extensive: epilepsy, organic pathology of the central nervous system, neuroinfections and other conditions. To verify the diagnosis, a comprehensive examination is required, including laboratory tests, tomography, and neurophysiological techniques. For the relief and therapy of convulsive syndrome, medications are used, in some cases, surgical treatment is indicated.