Hypofibrinogenemia is a pathological condition characterized by a decrease in the content of fibrinogen in the blood below 2 g / l. Fibrinogen is the main protein of the hemostasis system; a thrombus is formed from it, which stops bleeding when the vascular wall is damaged. Hypofibrinogenemia is clinically manifested by hemorrhagic syndrome and can develop as a result of complications of pregnancy, against the background of the administration of drugs, with severe liver diseases, etc. The level of fibrinogen is examined in the blood plasma as a component of the coagulogram along with INR, APTT, thrombin time. Correction of this condition is carried out by introducing fresh frozen plasma and eliminating the etiological factor.