Pain in the anus in men occurs with proctological diseases, some andrological pathologies. It can be short-term, long-term, constant, insignificant, moderate, strong, dull, sharp, burning, pressing, pulling, bursting, cutting, pulsating. Perhaps a combination with itching, burning, tenesmus, constipation, diarrhea, mucous or bloody discharge. To establish the etiology of the pain syndrome, a survey, external examination, ultrasound, sigmoidoscopy, anoscopy, and laboratory tests are performed. Treatment regimens include antibiotics, anti-inflammatory, analgesics, coating preparations, local procedures.