Hemoglobinuria is a series of syndromes, which are based on intravascular damage to red blood cells with the release of hemoglobin outside the vascular bed and into the urine. The main symptom of hemoglobinuria is the dark color of the urine due to the presence of oxyhemoglobin in it. Possible arthralgia, fever, vomiting, pallor of the skin, jaundice. The diagnosis of hemoglobinuria requires confirmation with the help of a complete blood and urine test, myelogram, functional and laboratory tests. Taking into account the pathogenetic form of hemoglobinuria, erythrocyte transfusion, the use of hormones, anticoagulants, splenectomy, and TCM can be indicated.