Pain in the cheekbone is observed with traumatic injuries, osteomyelitis, neuralgia, bruxism, myofascial syndrome, dental and otolaryngological diseases, some types of headache and facial pain. It can be dull, sharp, short-term, long-lasting, aching, bursting, twitching, shooting. Often occurs due to irradiation, combined with pain in neighboring anatomical structures. The cause of the symptom is established according to the survey, dental and otolaryngological examination, additional studies. Therapeutic measures include pain relief, etiopathogenetic therapy, surgical interventions.