Asymmetry of the nasolabial folds is a sign of a number of neurological diseases, occurs in some dental pathologies, and may be the result of aesthetic operations, cosmetic manipulations. The difference in depth and angles of inclination of the folds ranges from insignificant to pronounced. Pathology is often observed simultaneously with other types of facial asymmetry. The reason for the violation of the symmetry of the nasolabial folds is determined according to the survey, neurological examination, imaging and electrophysiological techniques. Treatment prior to diagnosis is not indicated.